| Venrock Healthcare Capital Partners III, L.P. |
DELAWARE |
20881288 |
20881288 |
20881288 |
0 |
20881288 |
9.9 % |
17/02/2026 |
| TCG Crossover GP I, LLC |
DELAWARE |
12362205 |
12362205 |
12362205 |
0 |
12362205 |
6.1 % |
17/02/2026 |
| Frazier Life Sciences Public Fund, L.P. |
DELAWARE |
8343048 |
8343048 |
8343048 |
0 |
8343048 |
4.1 % |
13/02/2026 |
| Nantahala Capital Management, LLC |
MASSACHUSETTS |
7344783 |
7344783 |
7344783 |
0 |
7344783 |
3.61 % |
13/02/2026 |
| Farallon Capital Partners, L.P. |
CALIFORNIA |
2488500 |
2488500 |
2488500 |
0 |
2488500 |
1.2 % |
05/02/2026 |
| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
10957322 |
5.4 % |
21/01/2026 |
| Venrock Healthcare Capital Partners III, L.P. |
DELAWARE |
12681043 |
12681043 |
12681043 |
0 |
12681043 |
7.3 % |
14/11/2025 |
| Nantahala Capital Management, LLC |
MASSACHUSETTS |
8775375 |
8775375 |
8775375 |
0 |
8775375 |
5.08 % |
14/11/2025 |
| Mohamad H. Makhzoumi |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| NEA 17 GP, LLC |
DE |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Forest Baskett |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Ali Behbahani |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Carmen Chang |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Rick Yang |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Paul Walker |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Scott D. Sandell |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Edward T. Mathers |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Growth Equity Opportunities 17, LLC |
DE |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| New Enterprise Associates 17, L.P. |
DE |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| NEA Partners 17, L.P. |
DE |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Anthony A. Florence, Jr. |
UNITED STATES |
0 |
24471264 |
0 |
24471264 |
24471264 |
12 % |
14/11/2025 |
| Vestal Point Capital, LP |
DELAWARE |
4015000 |
4015000 |
4015000 |
0 |
4015000 |
2.3 % |
14/11/2025 |
| Deerfield Mgmt, L.P. |
DELAWARE |
13569000 |
13569000 |
13569000 |
0 |
13569000 |
6.74 % |
05/11/2025 |
| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
8314875 |
4.8 % |
17/10/2025 |
| Frazier Life Sciences Public Fund, L.P. |
DELAWARE |
6745296 |
6745296 |
6745296 |
0 |
6745296 |
3.9 % |
14/08/2025 |
| Venrock Healthcare Capital Partners III, L.P. |
DELAWARE |
9021507 |
9021507 |
9021507 |
0 |
9021507 |
5.2 % |
08/07/2025 |
| Frazier Life Sciences Public Fund, L.P. |
DELAWARE |
6745296 |
6745296 |
6745296 |
0 |
6745296 |
3.9 % |
15/05/2025 |
| Bain Capital Life Sciences Fund II, L.P. |
E9 |
0 |
17600621 |
0 |
17600621 |
17600621 |
9.99 % |
27/03/2025 |
| BCLS II Investco, LP |
DE |
0 |
17600621 |
0 |
17600621 |
17600621 |
9.99 % |
27/03/2025 |
| BCIP Life Sciences Associates, LP |
DE |
0 |
17600621 |
0 |
17600621 |
17600621 |
9.99 % |
27/03/2025 |
| Vestal Point Capital, LP |
DELAWARE |
10775000 |
10775000 |
10775000 |
0 |
10775000 |
6.3 % |
14/02/2025 |
| Farallon Capital Partners, L.P. |
CALIFORNIA |
3159721 |
3159721 |
3159721 |
0 |
3159721 |
1.8 % |
11/02/2025 |
| Wellington Management Group LLP |
MASSACHUSETTS |
5481654 |
5481654 |
5481654 |
0 |
5481654 |
3.2 % |
10/02/2025 |
| Albert Cha |
Delaware |
0 |
7041586 |
0 |
7041586 |
7041586 |
4.1 % |
27/11/2024 |
| FHMLS XI, L.P. |
Delaware |
0 |
1369258 |
0 |
1369258 |
1369258 |
0.8 % |
27/11/2024 |
| Frazier Life Sciences XI, L.P. |
Delaware |
0 |
1369258 |
0 |
1369258 |
1369258 |
0.8 % |
27/11/2024 |
| FHMLS X, L.L.C. |
Delaware |
0 |
249535 |
0 |
249535 |
249535 |
0.1 % |
27/11/2024 |
| FHMLSP Overage, L.L.C. |
Delaware |
0 |
2298544 |
0 |
2298544 |
2298544 |
1.3 % |
27/11/2024 |
| Patrick J. Heron |
Delaware |
0 |
8660379 |
0 |
8660379 |
8660379 |
5 % |
27/11/2024 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
4743042 |
0 |
4743042 |
4743042 |
2.8 % |
27/11/2024 |
| FHMLSP, L.P. |
Delaware |
0 |
4743042 |
0 |
4743042 |
4743042 |
2.8 % |
27/11/2024 |
| FHMLSP, L.L.C. |
Delaware |
0 |
4743042 |
0 |
4743042 |
4743042 |
2.8 % |
27/11/2024 |
| Frazier Life Sciences Public Overage Fund, L.P. |
Delaware |
0 |
2298544 |
0 |
2298544 |
2298544 |
1.3 % |
27/11/2024 |
| FHMLSP Overage, L.P. |
Delaware |
0 |
2298544 |
0 |
2298544 |
2298544 |
1.3 % |
27/11/2024 |
| Frazier Life Sciences X, L.P. |
Delaware |
0 |
249535 |
0 |
249535 |
249535 |
0.1 % |
27/11/2024 |
| FHMLS X, L.P. |
Delaware |
0 |
249535 |
0 |
249535 |
249535 |
0.1 % |
27/11/2024 |
| FHMLS XI, L.L.C. |
Delaware |
0 |
1369258 |
0 |
1369258 |
1369258 |
0.8 % |
27/11/2024 |
| James N. Topper |
Delaware |
0 |
8660379 |
0 |
8660379 |
8660379 |
5 % |
27/11/2024 |
| James Brush |
Delaware |
0 |
7041586 |
0 |
7041586 |
7041586 |
4.1 % |
27/11/2024 |
| Daniel Estes |
Delaware |
0 |
1369258 |
0 |
1369258 |
1369258 |
0.8 % |
27/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
9399087 |
0 |
9399087 |
5.7 % |
08/11/2024 |
| Wellington Management Company LLP |
Massachusetts |
0 |
7350685 |
0 |
0 |
8413122 |
5.11 % |
08/11/2024 |
| Wellington Management Group LLP |
Massachusetts |
0 |
7350685 |
0 |
0 |
8624012 |
5.24 % |
08/11/2024 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
7350685 |
0 |
0 |
8624012 |
5.24 % |
08/11/2024 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
7350685 |
0 |
0 |
8624012 |
5.24 % |
08/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
9399087 |
0 |
9399087 |
5.7 % |
24/10/2024 |
| (1) BlackRock, Inc. |
Delaware |
7121108 |
0 |
7261530 |
0 |
7261530 |
5.4 % |
31/01/2024 |
| TCG Crossover GP I, LLC |
United States America |
0 |
10000000 |
0 |
10000000 |
10000000 |
7.4 % |
25/07/2023 |
| TCG Crossover Fund I, L.P. |
United States America |
0 |
10000000 |
0 |
10000000 |
10000000 |
7.4 % |
25/07/2023 |
| Chen Yu |
United States America |
0 |
10000000 |
0 |
10000000 |
10000000 |
7.4 % |
25/07/2023 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
6187282 |
0 |
6187282 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Co-Investment Holdings III, LLC |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Co-Investment Holdings III, LLC |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Management III, LLC |
Delaware |
0 |
6187282 |
0 |
6187282 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Co-Investment Holdings II, LLC |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| Shah, Nimish |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Management EG, LLC |
Delaware |
0 |
6187282 |
0 |
6187282 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Management II, LLC |
Delaware |
0 |
6187282 |
0 |
6187282 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Management III, LLC |
Delaware |
0 |
6187282 |
0 |
6187282 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Management EG, LLC |
Delaware |
0 |
6187282 |
0 |
6187282 |
6187282 |
5.4 % |
14/11/2022 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
6187282 |
0 |
6187282 |
6187282 |
5.4 % |
14/11/2022 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Management II, LLC |
Delaware |
0 |
6187282 |
0 |
6187282 |
6187282 |
5.4 % |
14/11/2022 |
| VHCP Co-Investment Holdings II, LLC |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| Koh, Bong |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| Koh, Bong |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| Shah, Nimish |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
6187282 |
0 |
0 |
6187282 |
5.4 % |
14/11/2022 |
| CDK Associates, L.L.C. |
Delaware |
0 |
6482759 |
0 |
6482759 |
6482759 |
5.7 % |
14/02/2022 |
| Bruce S. Kovner |
Delaware |
0 |
6896551 |
0 |
6896551 |
6896551 |
6.1 % |
14/02/2022 |
| Caxton Corporation |
Delaware |
0 |
6896551 |
0 |
6896551 |
6896551 |
6.1 % |
14/02/2022 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
2573254 |
0 |
2573254 |
2573254 |
11 % |
14/02/2022 |
| EcoR1 Capital, LLC |
Delaware |
0 |
3040540 |
0 |
3040540 |
3040540 |
11 % |
14/02/2022 |
| Oleg Nodelman |
Delaware |
0 |
3040540 |
0 |
3040540 |
3040540 |
11 % |
14/02/2022 |
| Robert Atchinson |
United States |
0 |
6864551 |
0 |
0 |
6864551 |
6.03 % |
10/02/2022 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
6864551 |
0 |
0 |
6864551 |
6.03 % |
10/02/2022 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
6864551 |
0 |
0 |
6864551 |
6.03 % |
10/02/2022 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
6864551 |
0 |
0 |
6864551 |
6.03 % |
10/02/2022 |
| Phillip Gross |
United States |
0 |
6864551 |
0 |
0 |
6864551 |
6.03 % |
10/02/2022 |
| Varun N. Gehani |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Four Crossings Institutional Partners V, L.P. |
|
0 |
399696 |
0 |
0 |
399696 |
0.4 % |
08/02/2022 |
| Farallon Capital F5 Master I, L.P. |
|
0 |
785745 |
0 |
0 |
785745 |
0.7 % |
08/02/2022 |
| Richard B. Fried |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Michael G. Linn |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| William Seybold |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Andrew J. M. Spokes |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| John R. Warren |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Mark C. Wehrly |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Richard B. Fried |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Thomas G. Roberts, Jr. |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Rajiv A. Patel |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Nicolas Giauque |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Varun N. Gehani |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Farallon Partners, L.L.C. |
|
0 |
10989887 |
0 |
0 |
10989887 |
9.3 % |
08/02/2022 |
| Farallon Capital Offshore Investors II, L.P. |
|
0 |
4902171 |
0 |
0 |
4902171 |
4.2 % |
08/02/2022 |
| Farallon Capital Institutional Partners III, L.P. |
|
0 |
301449 |
0 |
0 |
301449 |
0.3 % |
08/02/2022 |
| Farallon Capital Partners, L.P. |
|
0 |
2031477 |
0 |
0 |
2031477 |
1.8 % |
08/02/2022 |
| Farallon F5 (GP), L.L.C. |
|
0 |
785745 |
0 |
0 |
785745 |
0.7 % |
08/02/2022 |
| Philip D. Dreyfuss |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Nicolas Giauque |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Farallon Capital Institutional Partners, L.P. |
|
0 |
2635004 |
0 |
0 |
2635004 |
2.3 % |
08/02/2022 |
| Farallon Capital Institutional Partners II, L.P. |
|
0 |
514525 |
0 |
0 |
514525 |
0.5 % |
08/02/2022 |
| Farallon Capital (AM) Investors, L.P. |
|
0 |
205567 |
0 |
0 |
205567 |
0.2 % |
08/02/2022 |
| Farallon Institutional (GP) V, L.L.C. |
|
0 |
399696 |
0 |
0 |
399696 |
0.4 % |
08/02/2022 |
| Farallon F5 (GP), L.L.C. |
|
0 |
785745 |
0 |
0 |
785745 |
0.7 % |
08/02/2022 |
| Philip D. Dreyfuss |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Michael B. Fisch |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| David T. Kim |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Farallon Capital Institutional Partners, L.P. |
|
0 |
2635004 |
0 |
0 |
2635004 |
2.3 % |
08/02/2022 |
| Farallon Capital Institutional Partners II, L.P. |
|
0 |
514525 |
0 |
0 |
514525 |
0.5 % |
08/02/2022 |
| Farallon Capital Institutional Partners III, L.P. |
|
0 |
301449 |
0 |
0 |
301449 |
0.3 % |
08/02/2022 |
| Four Crossings Institutional Partners V, L.P. |
|
0 |
399696 |
0 |
0 |
399696 |
0.4 % |
08/02/2022 |
| Farallon Capital Offshore Investors II, L.P. |
|
0 |
4902171 |
0 |
0 |
4902171 |
4.2 % |
08/02/2022 |
| Farallon Capital (AM) Investors, L.P. |
|
0 |
205567 |
0 |
0 |
205567 |
0.2 % |
08/02/2022 |
| Farallon Capital Partners, L.P. |
|
0 |
2031477 |
0 |
0 |
2031477 |
1.8 % |
08/02/2022 |
| Farallon Capital F5 Master I, L.P. |
|
0 |
785745 |
0 |
0 |
785745 |
0.7 % |
08/02/2022 |
| David T. Kim |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Michael G. Linn |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Mark C. Wehrly |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| John R. Warren |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Andrew J. M. Spokes |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| William Seybold |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Farallon Partners, L.L.C. |
|
0 |
10989887 |
0 |
0 |
10989887 |
9.3 % |
08/02/2022 |
| Thomas G. Roberts, Jr. |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Rajiv A. Patel |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| Farallon Institutional (GP) V, L.L.C. |
|
0 |
399696 |
0 |
0 |
399696 |
0.4 % |
08/02/2022 |
| Michael B. Fisch |
|
0 |
11775632 |
0 |
0 |
11775632 |
9.99 % |
08/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
3038563 |
0 |
3128980 |
0 |
3128980 |
2.8 % |
09/04/2021 |
| Edward T. Mathers |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| New Enterprise Associates 17, L.P. |
Delaware Limited Partnership |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Forest Baskett |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Ali Behbahani |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Rick Yang |
States citizen |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Growth Equity Opportunities 17, LLC |
Delaware Limited Liability Company |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Paul Walker |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Peter W. Sonsini |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Anthony A. Florence, Jr. |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| NEA Partners 17, L.P. |
Delaware Limited Partnership |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Scott D. Sandell |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| NEA 17 GP, LLC |
Delaware Limited Liability Company |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Joshua Makower |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Liza Landsman |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Mohamad H. Makhzoumi |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Carmen Chang |
States |
0 |
24137931 |
0 |
24137931 |
24137931 |
24.2 % |
25/03/2021 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
7296551 |
0 |
0 |
7296551 |
6.53 % |
25/03/2021 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
7296551 |
0 |
0 |
7296551 |
6.53 % |
25/03/2021 |
| Robert Atchinson |
Delaware |
0 |
7296551 |
0 |
0 |
7296551 |
6.53 % |
25/03/2021 |
| Phillip Gross |
Delaware |
0 |
7296551 |
0 |
0 |
7296551 |
6.53 % |
25/03/2021 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
7296551 |
0 |
0 |
7296551 |
6.53 % |
25/03/2021 |
| CDK Associates, L.L.C. |
Delaware |
0 |
6482758 |
0 |
6482758 |
6482758 |
5.8 % |
19/03/2021 |
| Bruce S. Kovner |
Delaware |
0 |
6896551 |
0 |
6896551 |
6896551 |
6.2 % |
19/03/2021 |
| Caxton Corporation |
Delaware |
0 |
6896551 |
0 |
6896551 |
6896551 |
6.2 % |
19/03/2021 |
| EcoR1 Capital, LLC |
Delaware |
0 |
3040540 |
0 |
3040540 |
3040540 |
11 % |
16/02/2021 |
| Oleg Nodelman |
United States |
0 |
3040540 |
0 |
3040540 |
3040540 |
11 % |
16/02/2021 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
2573254 |
0 |
2573254 |
2573254 |
11 % |
16/02/2021 |
| Philip D. Dreyfuss |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Farallon Capital Institutional Partners, L.P. |
|
0 |
1187353 |
0 |
0 |
1187353 |
2.2 % |
12/02/2021 |
| Farallon Capital Institutional Partners III, L.P. |
|
0 |
132065 |
0 |
0 |
132065 |
0.2 % |
12/02/2021 |
| Michael B. Fisch |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Andrew J. M. Spokes |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Farallon Capital Institutional Partners, L.P. |
|
0 |
1187353 |
0 |
0 |
1187353 |
2.2 % |
12/02/2021 |
| Farallon Capital Institutional Partners II, L.P. |
|
0 |
204530 |
0 |
0 |
204530 |
0.4 % |
12/02/2021 |
| Michael B. Fisch |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Richard B. Fried |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| David T. Kim |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Michael G. Linn |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Rajiv A. Patel |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Thomas G. Roberts, Jr. |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| William Seybold |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Andrew J. M. Spokes |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| John R. Warren |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Mark C. Wehrly |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Farallon Capital Partners, L.P. |
|
0 |
1175284 |
0 |
0 |
1175284 |
2.2 % |
12/02/2021 |
| Four Crossings Institutional Partners V, L.P. |
|
0 |
179668 |
0 |
0 |
179668 |
0.3 % |
12/02/2021 |
| Farallon Capital Offshore Investors II, L.P. |
|
0 |
2338195 |
0 |
0 |
2338195 |
4.3 % |
12/02/2021 |
| Farallon Partners, L.L.C. |
|
0 |
5316619 |
0 |
0 |
5316619 |
9.6 % |
12/02/2021 |
| Farallon Institutional (GP) V, L.L.C. |
|
0 |
179668 |
0 |
0 |
179668 |
0.3 % |
12/02/2021 |
| David T. Kim |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Michael G. Linn |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Farallon Capital Institutional Partners II, L.P. |
|
0 |
204530 |
0 |
0 |
204530 |
0.4 % |
12/02/2021 |
| Farallon Capital (AM) Investors, L.P. |
|
0 |
99525 |
0 |
0 |
99525 |
0.2 % |
12/02/2021 |
| Farallon Capital F5 Master I, L.P. |
|
0 |
198268 |
0 |
0 |
198268 |
0.4 % |
12/02/2021 |
| Philip D. Dreyfuss |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Richard B. Fried |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Rajiv A. Patel |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Mark C. Wehrly |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Farallon Capital Institutional Partners III, L.P. |
|
0 |
132065 |
0 |
0 |
132065 |
0.2 % |
12/02/2021 |
| Four Crossings Institutional Partners V, L.P. |
|
0 |
179668 |
0 |
0 |
179668 |
0.3 % |
12/02/2021 |
| Farallon Capital Offshore Investors II, L.P. |
|
0 |
2338195 |
0 |
0 |
2338195 |
4.3 % |
12/02/2021 |
| Farallon Capital (AM) Investors, L.P. |
|
0 |
99525 |
0 |
0 |
99525 |
0.2 % |
12/02/2021 |
| Farallon Capital F5 Master I, L.P. |
|
0 |
198268 |
0 |
0 |
198268 |
0.4 % |
12/02/2021 |
| Farallon Partners, L.L.C. |
|
0 |
5316619 |
0 |
0 |
5316619 |
9.6 % |
12/02/2021 |
| Farallon Institutional (GP) V, L.L.C. |
|
0 |
179668 |
0 |
0 |
179668 |
0.3 % |
12/02/2021 |
| Farallon F5 (GP), L.L.C. |
|
0 |
198268 |
0 |
0 |
198268 |
0.4 % |
12/02/2021 |
| Farallon F5 (GP), L.L.C. |
|
0 |
198268 |
0 |
0 |
198268 |
0.4 % |
12/02/2021 |
| Thomas G. Roberts, Jr. |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| William Seybold |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| John R. Warren |
|
0 |
5514887 |
0 |
0 |
5514887 |
9.9 % |
12/02/2021 |
| Farallon Capital Partners, L.P. |
|
0 |
1175284 |
0 |
0 |
1175284 |
2.2 % |
12/02/2021 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
2573254 |
0 |
2573254 |
2573254 |
11 % |
12/02/2021 |
| Oleg Nodelman |
United States |
0 |
3040540 |
0 |
3040540 |
3040540 |
11 % |
12/02/2021 |
| EcoR1 Capital, LLC |
Delaware |
0 |
3040540 |
0 |
3040540 |
3040540 |
11 % |
12/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
2967238 |
0 |
3010030 |
0 |
3010030 |
5.6 % |
02/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
2268620 |
0 |
2299123 |
0 |
2299123 |
4.5 % |
09/04/2020 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Great Point Partners, LLC |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Mr. David Kroin |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Consonance Capital Opportunity Fund Management LP |
Delaware, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Consonance Capman GP LLC |
Delaware, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Mitchell Blutt |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Consonance Capital Management LP |
Delaware, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Richard B. Fried |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Thomas G. Roberts, Jr. |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Mark C. Wehrly |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| John R. Warren |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Rajiv A. Patel |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| David T. Kim |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Michael B. Fisch |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Philip D. Dreyfuss |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Farallon F5 (GP), L.L.C. |
|
0 |
183928 |
0 |
0 |
183928 |
0.4 % |
14/02/2020 |
| Farallon Institutional (GP) V, L.L.C. |
|
0 |
167100 |
0 |
0 |
167100 |
0.3 % |
14/02/2020 |
| William Seybold |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Rajiv A. Patel |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Michael G. Linn |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| David T. Kim |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Michael B. Fisch |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Philip D. Dreyfuss |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Farallon F5 (GP), L.L.C. |
|
0 |
183928 |
0 |
0 |
183928 |
0.4 % |
14/02/2020 |
| Farallon Institutional (GP) V, L.L.C. |
|
0 |
167100 |
0 |
0 |
167100 |
0.3 % |
14/02/2020 |
| Farallon Partners, L.L.C. |
|
0 |
4917660 |
0 |
0 |
4917660 |
9.6 % |
14/02/2020 |
| Farallon Capital F5 Master I, L.P. |
|
0 |
183928 |
0 |
0 |
183928 |
0.4 % |
14/02/2020 |
| Farallon Capital Offshore Investors II, L.P. |
|
0 |
2161438 |
0 |
0 |
2161438 |
4.3 % |
14/02/2020 |
| Four Crossings Institutional Partners V, L.P. |
|
0 |
167100 |
0 |
0 |
167100 |
0.3 % |
14/02/2020 |
| William Seybold |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Farallon Capital Partners, L.P. |
|
0 |
1084466 |
0 |
0 |
1084466 |
2.1 % |
14/02/2020 |
| Farallon Capital Institutional Partners, L.P. |
|
0 |
1099948 |
0 |
0 |
1099948 |
2.2 % |
14/02/2020 |
| Farallon Capital F5 Master I, L.P. |
|
0 |
183928 |
0 |
0 |
183928 |
0.4 % |
14/02/2020 |
| Farallon Partners, L.L.C. |
|
0 |
4917660 |
0 |
0 |
4917660 |
9.6 % |
14/02/2020 |
| Richard B. Fried |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Michael G. Linn |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Thomas G. Roberts, Jr. |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Monica R. Landry [See Item 2.] |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Farallon Capital (AM) Investors, L.P. |
|
0 |
91187 |
0 |
0 |
91187 |
0.2 % |
14/02/2020 |
| Farallon Capital Offshore Investors II, L.P. |
|
0 |
2161438 |
0 |
0 |
2161438 |
4.3 % |
14/02/2020 |
| Four Crossings Institutional Partners V, L.P. |
|
0 |
167100 |
0 |
0 |
167100 |
0.3 % |
14/02/2020 |
| Farallon Capital Institutional Partners III, L.P. |
|
0 |
123614 |
0 |
0 |
123614 |
0.2 % |
14/02/2020 |
| Farallon Capital Institutional Partners II, L.P. |
|
0 |
189907 |
0 |
0 |
189907 |
0.4 % |
14/02/2020 |
| Andrew J. M. Spokes |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Andrew J. M. Spokes |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| John R. Warren |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Mark C. Wehrly |
|
0 |
5101588 |
0 |
0 |
5101588 |
9.9 % |
14/02/2020 |
| Farallon Capital Partners, L.P. |
|
0 |
1084466 |
0 |
0 |
1084466 |
2.1 % |
14/02/2020 |
| Farallon Capital Institutional Partners, L.P. |
|
0 |
1099948 |
0 |
0 |
1099948 |
2.2 % |
14/02/2020 |
| Farallon Capital Institutional Partners II, L.P. |
|
0 |
189907 |
0 |
0 |
189907 |
0.4 % |
14/02/2020 |
| Farallon Capital Institutional Partners III, L.P. |
|
0 |
123614 |
0 |
0 |
123614 |
0.2 % |
14/02/2020 |
| Farallon Capital (AM) Investors, L.P. |
|
0 |
91187 |
0 |
0 |
91187 |
0.2 % |
14/02/2020 |
| Monica R. Landry [See Item 2.] |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
2236335 |
0 |
2270620 |
0 |
2270620 |
5.5 % |
06/02/2020 |
| Oleg Nodelman |
Delaware |
0 |
4473204 |
0 |
4473204 |
4473204 |
11 % |
06/01/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3717223 |
0 |
3717223 |
3717223 |
11 % |
06/01/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
4473204 |
0 |
4473204 |
4473204 |
11 % |
06/01/2020 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
2368000 |
0 |
0 |
2368000 |
6.27 % |
19/07/2019 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
2368000 |
0 |
0 |
2368000 |
6.27 % |
19/07/2019 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
2368000 |
0 |
0 |
2368000 |
6.27 % |
19/07/2019 |
| Mitchell Blutt |
USA |
0 |
3093690 |
0 |
0 |
3093690 |
8.82 % |
14/02/2019 |
| Consonance Capital Management LP |
Delaware, USA |
0 |
2962059 |
0 |
0 |
2962059 |
8.44 % |
14/02/2019 |
| Consonance Capital Opportunity Fund Management LP |
Delaware, USA |
0 |
131631 |
0 |
0 |
131631 |
0.38 % |
14/02/2019 |
| Consonance Capman GP LLC |
Delaware, USA |
0 |
3093690 |
0 |
0 |
3093690 |
8.82 % |
14/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
2159938 |
0 |
2199980 |
0 |
2199980 |
6.3 % |
07/02/2019 |
| Mr. David Kroin |
USA |
0 |
2243084 |
0 |
0 |
2243084 |
6.44 % |
06/08/2018 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2243084 |
0 |
0 |
2243084 |
6.44 % |
06/08/2018 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2243084 |
0 |
0 |
2243084 |
6.44 % |
06/08/2018 |
| Mr. David Kroin |
USA |
0 |
2243084 |
0 |
0 |
2243084 |
6.44 % |
06/08/2018 |
| Great Point Partners, LLC |
USA |
0 |
2243084 |
0 |
0 |
2243084 |
6.44 % |
06/08/2018 |
| Great Point Partners, LLC |
USA |
0 |
2243084 |
0 |
0 |
2243084 |
6.44 % |
06/08/2018 |
| Farallon F5 (GP), L.L.C. |
Delaware |
0 |
75026 |
0 |
0 |
75026 |
0.2 % |
15/02/2018 |
| Andrew J. M. Spokes |
United Kingdom |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Farallon Capital Management, L.L.C. [See Item 2] |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/02/2018 |
| David T. Kim |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Richard B. Fried |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Farallon Capital F5 Master I, L.P. |
Cayman Islands |
0 |
75026 |
0 |
0 |
75026 |
0.2 % |
15/02/2018 |
| Farallon Capital (AM) Investors, L.P. |
Delaware |
0 |
52574 |
0 |
0 |
52574 |
0.2 % |
15/02/2018 |
| Farallon Capital Offshore Investors II, L.P. |
Cayman Islands |
0 |
1253900 |
0 |
0 |
1253900 |
4 % |
15/02/2018 |
| Farallon Capital Institutional Partners V, L.P. |
Delaware |
0 |
101100 |
0 |
0 |
101100 |
0.3 % |
15/02/2018 |
| Farallon Capital Institutional Partners III, L.P. |
Delaware |
0 |
84400 |
0 |
0 |
84400 |
0.3 % |
15/02/2018 |
| Thomas G. Roberts, Jr. |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Farallon Capital Institutional Partners, L.P. |
California |
0 |
647700 |
0 |
0 |
647700 |
2.1 % |
15/02/2018 |
| Farallon Capital Institutional Partners II, L.P. |
California |
0 |
105000 |
0 |
0 |
105000 |
0.3 % |
15/02/2018 |
| William Seybold |
United Kingdom |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Mark C. Wehrly |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| John R. Warren |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Ravi K. Paidipaty [See Item 2] |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
15/02/2018 |
| Rajiv A. Patel |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Philip D. Dreyfuss |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Farallon Capital Partners, L.P. |
California |
0 |
680300 |
0 |
0 |
680300 |
2.2 % |
15/02/2018 |
| Monica R. Landry |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Farallon Institutional (GP) V, L.L.C. |
Delaware |
0 |
101100 |
0 |
0 |
101100 |
0.3 % |
15/02/2018 |
| Farallon Partners, L.L.C. |
Delaware |
0 |
2924974 |
0 |
0 |
2924974 |
9.4 % |
15/02/2018 |
| Michael G. Linn |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Michael B. Fisch |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
9.6 % |
15/02/2018 |
| Consonance Capital Management LP |
Delaware, USA |
0 |
2594310 |
0 |
0 |
2594310 |
8.51 % |
14/02/2018 |
| Consonance Capman GP LLC |
Delaware, USA |
0 |
2756012 |
0 |
0 |
2756012 |
9.04 % |
14/02/2018 |
| Consonance Capital Opportunity Fund Management LP |
Delaware, USA |
0 |
161702 |
0 |
0 |
161702 |
0.53 % |
14/02/2018 |
| Mitchell Blutt |
USA |
0 |
2756012 |
0 |
0 |
2756012 |
9.04 % |
14/02/2018 |
| Gabelli Funds, LLC |
Cayman Islands |
0 |
3047019 |
0 |
3047019 |
335500 |
5.51 % |
04/01/2018 |
| Ravi K. Paidipaty |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Andrew J. M. Spokes |
United Kingdom |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| John R. Warren |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Mark C. Wehrly |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Richard B. Fried |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Thomas G. Roberts, Jr. |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| William Seybold |
United Kingdom |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| David T. Kim |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Farallon Capital Partners, L.P. |
California |
0 |
511700 |
0 |
0 |
511700 |
2.2 % |
12/06/2017 |
| Farallon Capital Institutional Partners, L.P. |
California |
0 |
461700 |
0 |
0 |
461700 |
2 % |
12/06/2017 |
| Farallon Capital Institutional Partners II, L.P. |
California |
0 |
77900 |
0 |
0 |
77900 |
0.3 % |
12/06/2017 |
| Farallon Capital Institutional Partners III, L.P. |
Delaware |
0 |
61200 |
0 |
0 |
61200 |
0.3 % |
12/06/2017 |
| Farallon Capital Institutional Partners V, L.P. |
Delaware |
0 |
77900 |
0 |
0 |
77900 |
0.3 % |
12/06/2017 |
| Farallon Capital Offshore Investors II, L.P. |
Cayman Islands |
0 |
906700 |
0 |
0 |
906700 |
3.9 % |
12/06/2017 |
| Farallon Capital (AM) Investors, L.P. |
Delaware |
0 |
38974 |
0 |
0 |
38974 |
0.2 % |
12/06/2017 |
| Farallon Capital F5 Master I, L.P. |
Cayman Islands |
0 |
55626 |
0 |
0 |
55626 |
0.2 % |
12/06/2017 |
| Farallon Capital Management, L.L.C. |
Delaware |
0 |
33300 |
0 |
0 |
33300 |
0.1 % |
12/06/2017 |
| Farallon Partners, L.L.C. |
Delaware |
0 |
2136074 |
0 |
0 |
2136074 |
9.1 % |
12/06/2017 |
| Farallon Institutional (GP) V, L.L.C. |
Delaware |
0 |
77900 |
0 |
0 |
77900 |
0.3 % |
12/06/2017 |
| Farallon F5 (GP), L.L.C. |
Delaware |
0 |
55626 |
0 |
0 |
55626 |
0.2 % |
12/06/2017 |
| Philip D. Dreyfuss |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Michael B. Fisch |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Monica R. Landry |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Michael G. Linn |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Rajiv A. Patel |
United States |
0 |
2225000 |
0 |
0 |
2225000 |
9.5 % |
12/06/2017 |
| Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
12887614 |
0 |
12887614 |
12887614 |
6.69 % |
12/02/2016 |
| Southeastern Asset Management, Inc. |
Delaware |
4 |
4 |
4 |
4 |
2252900 |
4.5 % |
09/02/2016 |
| JCP Investment Partnership, LP |
Delaware |
4 |
4 |
4 |
4 |
258548 |
7.2 % |
04/02/2015 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
2093309 |
0 |
0 |
2093309 |
2.01 % |
14/02/2014 |
| James E. Flynn |
United States |
0 |
3934999 |
0 |
0 |
3934999 |
3.74 % |
14/02/2014 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
3934999 |
0 |
0 |
3934999 |
3.74 % |
14/02/2014 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
1841690 |
0 |
0 |
1841690 |
1.77 % |
14/02/2014 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
3934999 |
0 |
0 |
3934999 |
3.74 % |
14/02/2014 |
| Great Point Partners, LLC |
USA |
0 |
41949341 |
0 |
41949341 |
4194934 |
3.97 % |
14/02/2014 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
8700000 |
0 |
8700000 |
8700000 |
8.77 % |
24/06/2013 |
| Mr. David Kroin |
USA |
0 |
8700000 |
0 |
8700000 |
8700000 |
8.77 % |
24/06/2013 |
| Great Point Partners, LLC |
USA |
0 |
8700000 |
0 |
8700000 |
8700000 |
8.77 % |
24/06/2013 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
5981800 |
0 |
0 |
5981800 |
6.09 % |
21/06/2013 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
3260081 |
0 |
0 |
3260081 |
3.35 % |
21/06/2013 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
5981800 |
0 |
0 |
5981800 |
6.09 % |
21/06/2013 |
| James E. Flynn |
United States |
0 |
5981800 |
0 |
0 |
5981800 |
6.09 % |
21/06/2013 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
2721719 |
0 |
0 |
2721719 |
2.8 % |
21/06/2013 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
1006758 |
0 |
1006758 |
2.103 % |
10/01/2013 |
| FMR LLC |
Delaware |
0 |
0 |
1006758 |
0 |
1006758 |
2.103 % |
10/01/2013 |
| Gabelli Funds, LLC |
00 |
2 |
|
0 |
406303 |
3506706 |
3.45 % |
10/07/2012 |
| ACM Capital Partners, LLC |
Delaware USA |
0 |
1001238 |
0 |
1001238 |
1001238 |
2.1 % |
03/04/2012 |
| Jay Venkatesan |
Delaware USA |
0 |
1001238 |
0 |
1001238 |
1001238 |
2.1 % |
03/04/2012 |
| Ayer Capital Management, LP |
Delaware USA |
0 |
1001238 |
0 |
1001238 |
1001238 |
2.1 % |
03/04/2012 |
| RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2012 |
| Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2012 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2012 |
| TANG CAPITAL MANAGEMENT, LLC |
DELAWARE |
0 |
591250 |
0 |
591250 |
591250 |
1.2 % |
14/02/2012 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
591250 |
0 |
591250 |
591250 |
1.2 % |
14/02/2012 |
| KEVIN C. TANG |
UNITED STATES |
0 |
591250 |
0 |
591250 |
591250 |
1.2 % |
14/02/2012 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
4867110 |
0 |
4867110 |
9.992 % |
14/02/2012 |
| FMR LLC |
Delaware |
0 |
0 |
4867110 |
0 |
4867110 |
9.992 % |
14/02/2012 |
| Advisors, LLC |
Delaware |
0 |
2408734 |
0 |
2408734 |
2408734 |
4.9 % |
13/02/2012 |
| Kopin |
Delaware |
0 |
2408734 |
0 |
2408734 |
2408734 |
4.9 % |
13/02/2012 |
| Ayer Capital Management, LP |
Delaware USA |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.24 % |
21/11/2011 |
| 2. |
Delaware |
0 |
1805300 |
0 |
1805300 |
10 |
12 % |
21/11/2011 |
| 2. |
Delaware |
0 |
1805300 |
0 |
1805300 |
10 |
12 % |
21/11/2011 |
| (1) BlackRock, Inc. |
Delaware |
143436 |
0 |
143436 |
0 |
143436 |
0.54 % |
09/09/2011 |
| (1) BlackRock, Inc. |
Delaware |
2910662 |
0 |
2910662 |
0 |
2910662 |
11 % |
08/08/2011 |
| Kolchinsky |
Massachusetts |
2365000 |
0 |
2365000 |
0 |
2365000 |
9.9 % |
19/01/2011 |
| Capital Management, LLC |
Massachusetts |
2365000 |
0 |
2365000 |
0 |
2365000 |
9.9 % |
19/01/2011 |
| Capital Healthcare Fund, L.P. |
Massachusetts |
1182500 |
0 |
1182500 |
0 |
1182500 |
5 % |
19/01/2011 |
| TANG CAPITAL MANAGEMENT, LLC |
DELAWARE |
0 |
2229085 |
0 |
2229085 |
2229085 |
9.42 % |
18/01/2011 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
2229085 |
0 |
2229085 |
2229085 |
9.42 % |
18/01/2011 |
| KEVIN C. TANG |
UNITED STATES |
0 |
2229085 |
0 |
2229085 |
2229085 |
9.42 % |
18/01/2011 |
| Hartz Capital, Inc. |
State of New Jersey |
0 |
0 |
0 |
0 |
0 |
0 % |
02/06/2010 |
| Capital Investments, LLC |
of New Jersey |
1352753 |
0 |
1352753 |
0 |
1352753 |
13.1 % |
02/06/2010 |
| Capital, Inc. |
of New Jersey |
1352753 |
0 |
1352753 |
0 |
1352753 |
13.1 % |
02/06/2010 |
