| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
12136331 |
6.8 % |
24/04/2026 |
| The Vanguard Group |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
0 |
0 % |
27/03/2026 |
| Anson Funds Management LP |
TEXAS |
7481178 |
7481178 |
7481178 |
0 |
7481178 |
4.9 % |
17/02/2026 |
| Highbridge Capital Management, LLC |
DELAWARE |
0 |
0 |
0 |
0 |
6514658 |
3.7 % |
30/01/2026 |
| Anson Funds Management LP |
TEXAS |
6032938 |
6032938 |
6032938 |
0 |
6032938 |
5.7 % |
14/11/2025 |
| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
5686886 |
5.4 % |
17/10/2025 |
| Anson Funds Management LP |
TEXAS |
5225948 |
5225948 |
5225948 |
0 |
5225948 |
4.9 % |
14/08/2025 |
| The Vanguard Group |
PENNSYLVANIA |
126021 |
126021 |
126021 |
0 |
6694799 |
6.7 % |
29/07/2025 |
| Anson Funds Management LP |
TEXAS |
7579095 |
7579095 |
7579095 |
0 |
7579095 |
8.3 % |
15/05/2025 |
| Highbridge Capital Management, LLC |
State of Delaware |
0 |
2080054 |
0 |
0 |
2080054 |
6.5 % |
07/02/2024 |
| Heights Capital Management, Inc. |
Cayman Islands |
0 |
315249 |
0 |
315249 |
315249 |
2.7 % |
16/02/2021 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
315249 |
0 |
315249 |
315249 |
2.7 % |
16/02/2021 |
| s: Globis Capital Partners, L.P. |
Delaware |
0 |
141553 |
0 |
141553 |
141553 |
1.2 % |
12/02/2021 |
| (. |
United States |
190000 |
0 |
190000 |
0 |
190000 |
1.5 % |
14/12/2020 |
| 27-4413262 |
Maryland |
190000 |
0 |
190000 |
0 |
190000 |
1.5 % |
14/12/2020 |
| (. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/12/2020 |
| Globis Capital, L.L.C. |
Delaware |
0 |
497391 |
0 |
497391 |
497391 |
5.3 % |
21/09/2020 |
| s: Paul Packer |
Delaware |
0 |
497391 |
0 |
497391 |
497391 |
5.3 % |
21/09/2020 |
| Globis Capital Management, L.P. |
Delaware |
0 |
497391 |
0 |
497391 |
497391 |
5.3 % |
21/09/2020 |
| Globis Capital Advisors, L.L.C. |
Delaware |
0 |
497391 |
0 |
497391 |
497391 |
5.3 % |
21/09/2020 |
| Globis Capital Partners, L.P. |
Delaware |
0 |
497391 |
0 |
497391 |
497391 |
5.3 % |
21/09/2020 |
| (. |
Delaware |
59970 |
0 |
119940 |
0 |
119940 |
1.3 % |
25/08/2020 |
| 27-4413262 |
Maryland |
839581 |
0 |
936735 |
0 |
936735 |
9.9 % |
25/08/2020 |
| (. |
United States |
899551 |
0 |
936735 |
0 |
936735 |
9.9 % |
25/08/2020 |
| LLC |
Ontario Canada |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Winson |
Ontario Canada |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Kassam |
Ontario Canada |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Nathoo |
Ontario Canada |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Inc. |
Ontario Canada |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Management LP |
Ontario Canada |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
56000 |
0 |
0 |
56000 |
1.1 % |
14/02/2020 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
56000 |
0 |
0 |
56000 |
1.1 % |
14/02/2020 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
56000 |
0 |
0 |
56000 |
1.1 % |
14/02/2020 |
| Ari Zweiman |
Delaware |
0 |
38000 |
0 |
38000 |
38000 |
1 % |
13/02/2020 |
| 683 Capital Management, LLC |
Delaware |
0 |
38000 |
0 |
38000 |
38000 |
1 % |
13/02/2020 |
| 683 Capital Partners, LP |
Delaware |
0 |
38000 |
0 |
38000 |
38000 |
1 % |
13/02/2020 |
| Heights Capital Management, Inc. |
Delaware |
0 |
574384 |
0 |
574384 |
574384 |
9.9 % |
17/01/2020 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
574384 |
0 |
574384 |
574384 |
9.9 % |
17/01/2020 |
| 13G |
Texas |
0 |
5000000 |
0 |
5000000 |
5000000 |
9.7 % |
24/06/2019 |
| 13G |
Texas |
0 |
5000000 |
0 |
5000000 |
5000000 |
9.7 % |
24/06/2019 |
| 13G |
Texas |
0 |
5000000 |
0 |
5000000 |
5000000 |
9.7 % |
24/06/2019 |
| 13G |
Texas |
0 |
5000000 |
0 |
5000000 |
5000000 |
9.7 % |
24/06/2019 |
| 13G |
Texas |
0 |
5000000 |
0 |
5000000 |
5000000 |
9.7 % |
24/06/2019 |
| 13G |
Texas |
0 |
5000000 |
0 |
5000000 |
5000000 |
9.7 % |
24/06/2019 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
16666600 |
0 |
0 |
16666600 |
9.7 % |
24/06/2019 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
16666600 |
0 |
0 |
16666600 |
9.7 % |
24/06/2019 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
16666600 |
0 |
0 |
16666600 |
9.7 % |
24/06/2019 |
| Altium Capital Management, LP |
United State of America |
0 |
2800000 |
0 |
0 |
2800000 |
4.99 % |
13/02/2019 |
| Altium Growth GP, LLC |
United States of America |
0 |
2800000 |
0 |
0 |
2800000 |
4.99 % |
13/02/2019 |
| Altium Growth Fund, LP |
United States of America |
0 |
2800000 |
0 |
0 |
2800000 |
4.99 % |
13/02/2019 |
| Empery Tax Efficient II, LP |
Delaware |
0 |
1981086 |
0 |
0 |
1981086 |
4.99 % |
17/01/2019 |
| Ryan M. Lane |
United States |
0 |
3800000 |
0 |
0 |
3800000 |
4.99 % |
17/01/2019 |
| Martin D. Hoe |
United States |
0 |
3800000 |
0 |
0 |
3800000 |
4.99 % |
17/01/2019 |
| Empery Asset Master, Ltd. |
Cayman Islands |
0 |
1398008 |
0 |
0 |
1398008 |
4.99 % |
17/01/2019 |
| Empery Asset Management, LP |
Delaware |
0 |
3800000 |
0 |
0 |
3800000 |
4.99 % |
17/01/2019 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
2800000 |
0 |
0 |
2800000 |
9.81 % |
23/07/2018 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
2800000 |
0 |
0 |
2800000 |
9.81 % |
23/07/2018 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
2800000 |
0 |
0 |
2800000 |
9.81 % |
23/07/2018 |
| Ari Zweiman |
Delaware |
0 |
1275000 |
0 |
1275000 |
1275000 |
9.8 % |
23/07/2018 |
| 683 Capital Partners, LP |
Delaware |
0 |
1275000 |
0 |
1275000 |
1275000 |
9.8 % |
23/07/2018 |
| 683 Capital Management, LLC |
Delaware |
0 |
1275000 |
0 |
1275000 |
1275000 |
9.8 % |
23/07/2018 |
| Empery Tax Efficient II, LP |
Cayman Islands |
0 |
1981086 |
0 |
0 |
1981086 |
9.99 % |
18/07/2018 |
| Empery Asset Master, Ltd. |
Cayman Islands |
0 |
1398008 |
0 |
0 |
1398008 |
9.99 % |
18/07/2018 |
| Empery Asset Management, LP |
Cayman Islands |
0 |
3800000 |
0 |
0 |
3800000 |
9.99 % |
18/07/2018 |
| Empery Asset Management, LP |
Cayman Islands |
0 |
3800000 |
0 |
0 |
3800000 |
9.99 % |
18/07/2018 |
| Ryan M. Lane |
Cayman Islands |
0 |
3800000 |
0 |
0 |
3800000 |
9.99 % |
18/07/2018 |
| Martin D. Hoe |
Cayman Islands |
0 |
3800000 |
0 |
0 |
3800000 |
9.99 % |
18/07/2018 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
119451 |
0 |
119451 |
119451 |
2 % |
09/02/2018 |
| Heights Capital Management, Inc. |
Delaware |
0 |
119451 |
0 |
119451 |
119451 |
2 % |
09/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
588537 |
0 |
601573 |
0 |
601573 |
1.9 % |
09/03/2017 |
| Waqas Khatri |
Pakistan |
1517587 |
0 |
1517587 |
0 |
1517587 |
4.7 % |
17/02/2017 |
| Heights Capital Management, Inc. |
Delaware |
0 |
2980000 |
0 |
2980000 |
2980000 |
9.3 % |
17/02/2017 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
2980000 |
0 |
2980000 |
2980000 |
9.3 % |
17/02/2017 |
| Heights Capital Management, Inc. |
Delaware |
0 |
569901 |
0 |
569901 |
569901 |
4.9 % |
10/02/2017 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
569901 |
0 |
569901 |
569901 |
4.9 % |
10/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
600845 |
0 |
613881 |
0 |
613881 |
5.7 % |
30/01/2017 |
| (1) BlackRock, Inc. |
Delaware |
10415153 |
0 |
10677669 |
0 |
10677669 |
4.99 % |
09/09/2016 |
| Heights Capital Management, Inc. |
Delaware |
0 |
14000000 |
0 |
14000000 |
14000000 |
6.7 % |
15/07/2016 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
14000000 |
0 |
14000000 |
14000000 |
6.7 % |
15/07/2016 |
| Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
4000000 |
0 |
4000000 |
10000200 |
4.77 % |
12/07/2016 |
| (1) BlackRock, Inc. |
Delaware |
8818754 |
0 |
9049327 |
0 |
9049327 |
5.6 % |
26/01/2016 |
| (1) BlackRock, Inc. |
Delaware |
7592767 |
0 |
7764546 |
0 |
7764546 |
6.4 % |
30/01/2015 |
| (1) BlackRock, Inc. |
Delaware |
6464674 |
0 |
6645931 |
0 |
6645931 |
6.3 % |
28/01/2014 |
| Sabby Healthcare Volatility Master Fund, Ltd. |
Delaware USA |
0 |
4649000 |
0 |
4649000 |
3399000 |
4.1 % |
02/01/2013 |
| TANG CAPITAL MANAGEMENT, LLC |
DELAWARE |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2012 |
| KEVIN C. TANG |
UNITED STATES |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2012 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2012 |
| TANG CAPITAL MANAGEMENT, LLC |
DELAWARE |
0 |
1779845 |
0 |
1779845 |
1779845 |
9.69 % |
06/01/2011 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
1779845 |
0 |
1779845 |
1779845 |
9.69 % |
06/01/2011 |
| KEVIN C. TANG |
UNITED STATES |
0 |
1779845 |
0 |
1779845 |
1779845 |
9.69 % |
06/01/2011 |
| TANG CAPITAL MANAGEMENT, LLC |
DELAWARE |
0 |
952369 |
0 |
952369 |
952369 |
5.18 % |
12/07/2010 |
| KEVIN C. TANG |
UNITED STATES |
0 |
952369 |
0 |
952369 |
952369 |
5.18 % |
12/07/2010 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
952369 |
0 |
952369 |
952369 |
5.18 % |
12/07/2010 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
662857 |
0 |
662857 |
4.067 % |
16/02/2010 |
| FMR LLC |
Delaware |
0 |
0 |
662857 |
0 |
662857 |
4.067 % |
16/02/2010 |
| BAM Opportunity Fund, L.P. |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2010 |
| BAM Opportunity Fund SPV, LLC |
Delaware USA |
0 |
408514 |
0 |
0 |
408514 |
2.46 % |
07/01/2010 |
| Ross Berman |
Delaware USA |
0 |
408514 |
0 |
0 |
408514 |
2.46 % |
07/01/2010 |
| BAM Management, LLC |
Delaware USA |
0 |
408514 |
0 |
0 |
408514 |
2.46 % |
07/01/2010 |
| Hal Mintz |
Delaware USA |
0 |
408514 |
0 |
0 |
408514 |
2.46 % |
07/01/2010 |
| BAM Capital, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2010 |
| BAM Capital, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2010 |
| BAM Opportunity Fund, L.P. |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2010 |
| Hal Mintz |
Delaware USA |
0 |
408514 |
0 |
0 |
408514 |
2.46 % |
07/01/2010 |
| Ross Berman |
Delaware USA |
0 |
408514 |
0 |
0 |
408514 |
2.46 % |
07/01/2010 |
| BAM Opportunity Fund SPV, LLC |
Delaware USA |
0 |
408514 |
0 |
0 |
408514 |
2.46 % |
07/01/2010 |
| BAM Management, LLC |
Delaware USA |
0 |
408514 |
0 |
0 |
408514 |
2.46 % |
07/01/2010 |
| FMR LLC |
Delaware |
0 |
0 |
1061997 |
0 |
1061997 |
6.516 % |
10/11/2009 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1061997 |
0 |
1061997 |
6.516 % |
10/11/2009 |
| BAM Opportunity Fund, L.P. |
Delaware, U.S.A. |
0 |
1021286 |
0 |
0 |
1021286 |
6.3 % |
05/08/2009 |
| Ross Berman |
United States of America |
0 |
1021286 |
0 |
0 |
1021286 |
6.3 % |
05/08/2009 |
| BAM Management, LLC |
Delaware, U.S.A. |
0 |
1021286 |
0 |
0 |
1021286 |
6.3 % |
05/08/2009 |
| BAM Capital, LLC |
Delaware, U.S.A. |
0 |
1021286 |
0 |
0 |
1021286 |
6.3 % |
05/08/2009 |
| Hal Mintz |
United States of America |
0 |
1021286 |
0 |
0 |
1021286 |
6.3 % |
05/08/2009 |
| FMR LLC |
Delaware |
1500 |
0 |
1855684 |
0 |
1855684 |
13.483 % |
17/02/2009 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1855684 |
0 |
1855684 |
13.483 % |
17/02/2009 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
2049622 |
0 |
2049622 |
14.898 % |
10/07/2008 |
| FMR LLC |
Delaware |
1500 |
0 |
2049622 |
0 |
2049622 |
14.898 % |
10/07/2008 |