Rhythm Pharmaceuticals, Inc.

RYTM

Individual Beneficiary

Name of reporting person Citizenship or organization Sole voting power Shared voting power Sole dispositive power Shared dispositive power Amount beneficially owned Percent of class Accepted date
Perceptive Advisors LLC DELAWARE 3519626 3519626 3519626 0 3519626 5.1 % 15/05/2026
Vanguard Capital Management PENNSYLVANIA 0 0 0 0 3432949 5.02 % 30/04/2026
The Vanguard Group PENNSYLVANIA 0 0 0 0 0 0 % 27/03/2026
RA Capital Management, L.P. DELAWARE 6666837 6666837 6666837 0 6666837 9.9 % 17/02/2026
PRIMECAP MANAGEMENT CO/CA/ UNITED STATES 0 0 0 0 3478669 5.21 % 12/02/2026
The Vanguard Group PENNSYLVANIA 6210916 6210916 6210916 0 6210916 9.3 % 30/01/2026
PRIMECAP MANAGEMENT CO/CA/ UNITED STATES 0 0 0 0 4262859 6.42 % 14/11/2025
The Vanguard Group PENNSYLVANIA 466791 466791 466791 0 4996427 7.52 % 30/10/2025
RA Capital Management, L.P. DELAWARE 5561359 5561359 5561359 0 5561359 8.7 % 14/08/2025
PRIMECAP MANAGEMENT CO/CA/ UNITED STATES 0 0 0 0 4878037 7.67 % 14/08/2025
Perceptive Advisors LLC DELAWARE 4423441 4423441 4423441 0 4423441 6.8 % 15/05/2025
Baker Bros. Advisors LP DELAWARE 0 0 0 0 5604483 8.9 % 15/05/2025
PRIMECAP MANAGEMENT CO/CA/ UNITED STATES 0 0 0 0 5787322 9.15 % 13/05/2025
BlackRock, Inc. DELAWARE 0 0 0 0 4364700 6.9 % 24/04/2025
PRIMECAP MANAGEMENT CO/CA/ UNITED STATES 0 0 0 0 6571190 10.69 % 13/02/2025
THE GOLDMAN SACHS GROUP, INC. DELAWARE 1818922 1818922 1818922 0 1818931 3 % 10/02/2025
Perceptive Discovery ID LP Delaware 0 1458330 0 1458330 1458330 2.3 % 14/11/2024
Perceptive Life Sciences Master Fund, Ltd. Delaware 0 3976880 0 3976880 3976880 6.3 % 14/11/2024
Perceptive Advisors LLC Delaware 0 5435210 0 5435210 5435210 8.6 % 14/11/2024
Joseph Edelman Delaware 0 5435210 0 5435210 5435210 8.6 % 14/11/2024
Joseph Edelman 0 3268579 0 3268579 3268579 5.4 % 20/03/2024
Perceptive Advisors LLC 0 3268579 0 3268579 3268579 5.4 % 20/03/2024
Perceptive Life Sciences Master Fund, Ltd. 0 3268579 0 3268579 3268579 5.4 % 20/03/2024
The Vanguard Group - 23-1945930 Pennsylvania 0 93382 3089760 0 3226938 5.46 % 13/02/2024
Joseph Edelman Delaware 0 3260013 0 3260013 3260013 5.5 % 12/02/2024
Perceptive Advisors LLC Delaware 0 3260013 0 3260013 3260013 5.5 % 12/02/2024
Perceptive Life Sciences Master Fund, Ltd. Delaware 0 3260013 0 3260013 3260013 5.5 % 12/02/2024
SSGA FUNDS MANAGEMENT, INC. 0 2933387 0 2933387 2933387 5.21 % 03/02/2023
STATE STREET CORPORATION 0 3137350 0 3180698 3180698 5.64 % 03/02/2023
(1) BlackRock, Inc. Delaware 3683867 0 3723714 0 3723714 6.6 % 03/02/2023
Baker Bros. Advisors LP Delaware 6062702 0 6062702 0 6062702 10.9 % 07/10/2022
(1) BlackRock, Inc. Delaware 1156750 0 1177575 0 1177575 2.3 % 08/07/2022
Voting Shares Irrevocable Trust Citizenship or place of Organization 5065113 0 5065113 0 5065113 10.06 % 11/04/2022
J. Christopher Donahue Citizenship or place of Organization 0 5065113 0 5065113 5065113 10.06 % 11/04/2022
Thomas R. Donahue Citizenship or place of Organization 0 5065113 0 5065113 5065113 10.06 % 11/04/2022
Federated Hermes, Inc. Citizenship or place of Organization 5065113 0 5065113 0 5065113 10.06 % 11/04/2022
Rhodora J. Donahue Citizenship or place of Organization 0 5065113 0 5065113 5065113 10.06 % 11/04/2022
J. Christopher Donahue Citizenship or place of Organization 0 2803335 0 2803335 2803335 5.58 % 14/02/2022
Rhodora J. Donahue Citizenship or place of Organization 0 2803335 0 2803335 2803335 5.58 % 14/02/2022
Thomas R. Donahue Citizenship or place of Organization 0 2803335 0 2803335 2803335 5.58 % 14/02/2022
Federated Hermes, Inc. Citizenship or place of Organization 2803335 0 2803335 0 2803335 5.58 % 14/02/2022
Voting Shares Irrevocable Trust Citizenship or place of Organization 2803335 0 2803335 0 2803335 5.58 % 14/02/2022
EIN #00-0000000 Jersey, Channel Islands 0 3133935 0 3133935 3133935 6.2 % 10/02/2022
(1) BlackRock, Inc. Delaware 3248859 0 3328061 0 3328061 6.6 % 03/02/2022
THE GOLDMAN SACHS GROUP, INC. New York 13 3057449 0 3057559 3057559 6.1 % 24/01/2022
GOLDMAN SACHS & CO. LLC New York 13 3057449 0 3057559 3057559 6.1 % 24/01/2022
Federated Hermes, Inc. Citizenship or place of Organization 1775704 0 1775704 0 1775704 3.53 % 10/12/2021
Voting Shares Irrevocable Trust Citizenship or place of Organization 1775704 0 1775704 0 1775704 3.53 % 10/12/2021
Thomas R. Donahue Citizenship or place of Organization 0 1775704 0 1775704 1775704 3.53 % 10/12/2021
Rhodora J. Donahue Citizenship or place of Organization 0 1775704 0 1775704 1775704 3.53 % 10/12/2021
J. Christopher Donahue Citizenship or place of Organization 0 1775704 0 1775704 1775704 3.53 % 10/12/2021
s. 177 E. Colorado Blvd., 11th Floor, Pasadena, CA 91105 5570691 0 5570691 0 5570691 11.14 % 08/03/2021
Voting Shares Irrevocable Trust Citizenship or place of Organization 2617600 0 2617600 0 2617600 5.92 % 12/02/2021
Federated Hermes, Inc. Citizenship or place of Organization 2617600 0 2617600 0 2617600 5.92 % 12/02/2021
Thomas R. Donahue Citizenship or place of Organization 0 2617600 0 2617600 2617600 5.92 % 12/02/2021
Rhodora J. Donahue Citizenship or place of Organization 0 2617600 0 2617600 2617600 5.92 % 12/02/2021
J. Christopher Donahue Citizenship or place of Organization 0 2617600 0 2617600 2617600 5.92 % 12/02/2021
(. Citizenship or Place of Organization 4342491 0 4342491 0 4342491 9.82 % 12/02/2021
EIN #00-0000000 Jersey, Channel Islands 0 4491765 0 4491765 4491765 10.2 % 11/02/2021
Wellington Management Group LLP Massachusetts 0 1925212 0 2101227 2101227 4.75 % 04/02/2021
(1) BlackRock, Inc. Delaware 2700024 0 2731106 0 2731106 6.2 % 01/02/2021
PRIMECAP Management Company 95-3868081 3542591 0 3542591 0 3542591 8.04 % 24/04/2020
(1) BlackRock, Inc. Delaware 2506618 0 2554766 0 2554766 5.8 % 07/02/2020
Wellington Management Group LLP Massachusetts 0 3082138 0 0 3320751 7.56 % 28/01/2020
Wellington Group Holdings LLP Massachusetts 0 3082138 0 0 3320751 7.56 % 28/01/2020
Wellington Investment Advisors Holdings LLP Massachusetts 0 3082138 0 0 3320751 7.56 % 28/01/2020
Wellington Management Company LLP Massachusetts 0 3026983 0 0 3186449 7.25 % 28/01/2020
Deerfield Mgmt, L.P. Delaware 0 1458000 0 1458000 1458000 4.22 % 19/08/2019
RA Capital Management, LLC Massachusetts 0 1950332 0 1950332 1950332 5.7 % 14/02/2019
Peter Kolchinsky United States 0 1950332 0 1950332 1950332 5.7 % 14/02/2019
Sabby Volatility Warrant Master Fund, Ltd. Jersey Channel Islands 0 3263175 0 3263175 16666600 9.89 % 12/02/2019
Baker Bros. Advisors (GP) LLC Delaware 2049020 0 2049020 0 2049020 7.5 % 13/02/2018
Baker Bros. Advisors LP Delaware 2049020 0 2049020 0 2049020 7.5 % 13/02/2018
Felix J. Baker Delaware 2049020 0 2049020 0 2049020 7.5 % 13/02/2018
Julian C. Baker Delaware 2049020 0 2049020 0 2049020 7.5 % 13/02/2018
10. United States 0 3981437 0 3981437 3981437 14.6 % 13/02/2018
10. United States 0 3981437 0 3981437 0 14.6 % 13/02/2018
10. United States 0 3981437 0 3981437 0 14.6 % 13/02/2018
10. United States 0 3981437 0 3981437 0 14.6 % 13/02/2018
10. United States 0 3981437 0 3981437 3981437 14.6 % 13/02/2018
10. United States 0 3981437 0 3981437 3981437 14.6 % 13/02/2018
OrbiMed Advisors LLC Delaware 0 2901295 0 10 2901295 10.7 % 20/10/2017
OrbiMed Capital GP V LLC Delaware 0 2901295 0 10 2901295 10.7 % 20/10/2017
Samuel D. Isaly Delaware 0 2901295 0 10 2901295 10.7 % 20/10/2017
YORKTOWN ENERGY PARTNERS X, L.P. Delaware 1427639 7 1427639 0 10954234 36.1 % 18/10/2017
Fund, L.P. Delaware 0 468505 0 0 468505 1.8 % 10/10/2017
James E. Flynn Delaware 0 937010 0 0 937010 3.59 % 10/10/2017
Deerfield Private Design Fund III, L.P. Delaware 0 468505 0 0 468505 1.8 % 10/10/2017
Deerfield Mgmt, L.P. Delaware 0 468505 0 0 468505 1.8 % 10/10/2017
Company, L.P. Delaware 0 937010 0 0 937010 3.59 % 10/10/2017
Mgmt III, L.P. Delaware 0 468505 0 0 468505 1.8 % 10/10/2017

Senat trading

Bureau Date de la transaction Date de réception Type Amount Commentaire

Senat Divulgation

Représentant Date de la transaction Date de divulgation Type Amount District