| Perceptive Advisors LLC |
DELAWARE |
3519626 |
3519626 |
3519626 |
0 |
3519626 |
5.1 % |
15/05/2026 |
| Vanguard Capital Management |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
3432949 |
5.02 % |
30/04/2026 |
| The Vanguard Group |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
0 |
0 % |
27/03/2026 |
| RA Capital Management, L.P. |
DELAWARE |
6666837 |
6666837 |
6666837 |
0 |
6666837 |
9.9 % |
17/02/2026 |
| PRIMECAP MANAGEMENT CO/CA/ |
UNITED STATES |
0 |
0 |
0 |
0 |
3478669 |
5.21 % |
12/02/2026 |
| The Vanguard Group |
PENNSYLVANIA |
6210916 |
6210916 |
6210916 |
0 |
6210916 |
9.3 % |
30/01/2026 |
| PRIMECAP MANAGEMENT CO/CA/ |
UNITED STATES |
0 |
0 |
0 |
0 |
4262859 |
6.42 % |
14/11/2025 |
| The Vanguard Group |
PENNSYLVANIA |
466791 |
466791 |
466791 |
0 |
4996427 |
7.52 % |
30/10/2025 |
| RA Capital Management, L.P. |
DELAWARE |
5561359 |
5561359 |
5561359 |
0 |
5561359 |
8.7 % |
14/08/2025 |
| PRIMECAP MANAGEMENT CO/CA/ |
UNITED STATES |
0 |
0 |
0 |
0 |
4878037 |
7.67 % |
14/08/2025 |
| Perceptive Advisors LLC |
DELAWARE |
4423441 |
4423441 |
4423441 |
0 |
4423441 |
6.8 % |
15/05/2025 |
| Baker Bros. Advisors LP |
DELAWARE |
0 |
0 |
0 |
0 |
5604483 |
8.9 % |
15/05/2025 |
| PRIMECAP MANAGEMENT CO/CA/ |
UNITED STATES |
0 |
0 |
0 |
0 |
5787322 |
9.15 % |
13/05/2025 |
| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
4364700 |
6.9 % |
24/04/2025 |
| PRIMECAP MANAGEMENT CO/CA/ |
UNITED STATES |
0 |
0 |
0 |
0 |
6571190 |
10.69 % |
13/02/2025 |
| THE GOLDMAN SACHS GROUP, INC. |
DELAWARE |
1818922 |
1818922 |
1818922 |
0 |
1818931 |
3 % |
10/02/2025 |
| Perceptive Discovery ID LP |
Delaware |
0 |
1458330 |
0 |
1458330 |
1458330 |
2.3 % |
14/11/2024 |
| Perceptive Life Sciences Master Fund, Ltd. |
Delaware |
0 |
3976880 |
0 |
3976880 |
3976880 |
6.3 % |
14/11/2024 |
| Perceptive Advisors LLC |
Delaware |
0 |
5435210 |
0 |
5435210 |
5435210 |
8.6 % |
14/11/2024 |
| Joseph Edelman |
Delaware |
0 |
5435210 |
0 |
5435210 |
5435210 |
8.6 % |
14/11/2024 |
| Joseph Edelman |
|
0 |
3268579 |
0 |
3268579 |
3268579 |
5.4 % |
20/03/2024 |
| Perceptive Advisors LLC |
|
0 |
3268579 |
0 |
3268579 |
3268579 |
5.4 % |
20/03/2024 |
| Perceptive Life Sciences Master Fund, Ltd. |
|
0 |
3268579 |
0 |
3268579 |
3268579 |
5.4 % |
20/03/2024 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
93382 |
3089760 |
0 |
3226938 |
5.46 % |
13/02/2024 |
| Joseph Edelman |
Delaware |
0 |
3260013 |
0 |
3260013 |
3260013 |
5.5 % |
12/02/2024 |
| Perceptive Advisors LLC |
Delaware |
0 |
3260013 |
0 |
3260013 |
3260013 |
5.5 % |
12/02/2024 |
| Perceptive Life Sciences Master Fund, Ltd. |
Delaware |
0 |
3260013 |
0 |
3260013 |
3260013 |
5.5 % |
12/02/2024 |
| SSGA FUNDS MANAGEMENT, INC. |
|
0 |
2933387 |
0 |
2933387 |
2933387 |
5.21 % |
03/02/2023 |
| STATE STREET CORPORATION |
|
0 |
3137350 |
0 |
3180698 |
3180698 |
5.64 % |
03/02/2023 |
| (1) BlackRock, Inc. |
Delaware |
3683867 |
0 |
3723714 |
0 |
3723714 |
6.6 % |
03/02/2023 |
| Baker Bros. Advisors LP |
Delaware |
6062702 |
0 |
6062702 |
0 |
6062702 |
10.9 % |
07/10/2022 |
| (1) BlackRock, Inc. |
Delaware |
1156750 |
0 |
1177575 |
0 |
1177575 |
2.3 % |
08/07/2022 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
5065113 |
0 |
5065113 |
0 |
5065113 |
10.06 % |
11/04/2022 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
5065113 |
0 |
5065113 |
5065113 |
10.06 % |
11/04/2022 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
5065113 |
0 |
5065113 |
5065113 |
10.06 % |
11/04/2022 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
5065113 |
0 |
5065113 |
0 |
5065113 |
10.06 % |
11/04/2022 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
5065113 |
0 |
5065113 |
5065113 |
10.06 % |
11/04/2022 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
2803335 |
0 |
2803335 |
2803335 |
5.58 % |
14/02/2022 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
2803335 |
0 |
2803335 |
2803335 |
5.58 % |
14/02/2022 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
2803335 |
0 |
2803335 |
2803335 |
5.58 % |
14/02/2022 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
2803335 |
0 |
2803335 |
0 |
2803335 |
5.58 % |
14/02/2022 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
2803335 |
0 |
2803335 |
0 |
2803335 |
5.58 % |
14/02/2022 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
3133935 |
0 |
3133935 |
3133935 |
6.2 % |
10/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
3248859 |
0 |
3328061 |
0 |
3328061 |
6.6 % |
03/02/2022 |
| THE GOLDMAN SACHS GROUP, INC. |
New York |
13 |
3057449 |
0 |
3057559 |
3057559 |
6.1 % |
24/01/2022 |
| GOLDMAN SACHS & CO. LLC |
New York |
13 |
3057449 |
0 |
3057559 |
3057559 |
6.1 % |
24/01/2022 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
1775704 |
0 |
1775704 |
0 |
1775704 |
3.53 % |
10/12/2021 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
1775704 |
0 |
1775704 |
0 |
1775704 |
3.53 % |
10/12/2021 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
1775704 |
0 |
1775704 |
1775704 |
3.53 % |
10/12/2021 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
1775704 |
0 |
1775704 |
1775704 |
3.53 % |
10/12/2021 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
1775704 |
0 |
1775704 |
1775704 |
3.53 % |
10/12/2021 |
| s. |
177 E. Colorado Blvd., 11th Floor, Pasadena, CA 91105 |
5570691 |
0 |
5570691 |
0 |
5570691 |
11.14 % |
08/03/2021 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
2617600 |
0 |
2617600 |
0 |
2617600 |
5.92 % |
12/02/2021 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
2617600 |
0 |
2617600 |
0 |
2617600 |
5.92 % |
12/02/2021 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
2617600 |
0 |
2617600 |
2617600 |
5.92 % |
12/02/2021 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
2617600 |
0 |
2617600 |
2617600 |
5.92 % |
12/02/2021 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
2617600 |
0 |
2617600 |
2617600 |
5.92 % |
12/02/2021 |
| (. |
Citizenship or Place of Organization |
4342491 |
0 |
4342491 |
0 |
4342491 |
9.82 % |
12/02/2021 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
4491765 |
0 |
4491765 |
4491765 |
10.2 % |
11/02/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1925212 |
0 |
2101227 |
2101227 |
4.75 % |
04/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
2700024 |
0 |
2731106 |
0 |
2731106 |
6.2 % |
01/02/2021 |
| PRIMECAP Management Company 95-3868081 |
|
3542591 |
0 |
3542591 |
0 |
3542591 |
8.04 % |
24/04/2020 |
| (1) BlackRock, Inc. |
Delaware |
2506618 |
0 |
2554766 |
0 |
2554766 |
5.8 % |
07/02/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3082138 |
0 |
0 |
3320751 |
7.56 % |
28/01/2020 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
3082138 |
0 |
0 |
3320751 |
7.56 % |
28/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
3082138 |
0 |
0 |
3320751 |
7.56 % |
28/01/2020 |
| Wellington Management Company LLP |
Massachusetts |
0 |
3026983 |
0 |
0 |
3186449 |
7.25 % |
28/01/2020 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1458000 |
0 |
1458000 |
1458000 |
4.22 % |
19/08/2019 |
| RA Capital Management, LLC |
Massachusetts |
0 |
1950332 |
0 |
1950332 |
1950332 |
5.7 % |
14/02/2019 |
| Peter Kolchinsky |
United States |
0 |
1950332 |
0 |
1950332 |
1950332 |
5.7 % |
14/02/2019 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Jersey Channel Islands |
0 |
3263175 |
0 |
3263175 |
16666600 |
9.89 % |
12/02/2019 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
2049020 |
0 |
2049020 |
0 |
2049020 |
7.5 % |
13/02/2018 |
| Baker Bros. Advisors LP |
Delaware |
2049020 |
0 |
2049020 |
0 |
2049020 |
7.5 % |
13/02/2018 |
| Felix J. Baker |
Delaware |
2049020 |
0 |
2049020 |
0 |
2049020 |
7.5 % |
13/02/2018 |
| Julian C. Baker |
Delaware |
2049020 |
0 |
2049020 |
0 |
2049020 |
7.5 % |
13/02/2018 |
| 10. |
United States |
0 |
3981437 |
0 |
3981437 |
3981437 |
14.6 % |
13/02/2018 |
| 10. |
United States |
0 |
3981437 |
0 |
3981437 |
0 |
14.6 % |
13/02/2018 |
| 10. |
United States |
0 |
3981437 |
0 |
3981437 |
0 |
14.6 % |
13/02/2018 |
| 10. |
United States |
0 |
3981437 |
0 |
3981437 |
0 |
14.6 % |
13/02/2018 |
| 10. |
United States |
0 |
3981437 |
0 |
3981437 |
3981437 |
14.6 % |
13/02/2018 |
| 10. |
United States |
0 |
3981437 |
0 |
3981437 |
3981437 |
14.6 % |
13/02/2018 |
| OrbiMed Advisors LLC |
Delaware |
0 |
2901295 |
0 |
10 |
2901295 |
10.7 % |
20/10/2017 |
| OrbiMed Capital GP V LLC |
Delaware |
0 |
2901295 |
0 |
10 |
2901295 |
10.7 % |
20/10/2017 |
| Samuel D. Isaly |
Delaware |
0 |
2901295 |
0 |
10 |
2901295 |
10.7 % |
20/10/2017 |
| YORKTOWN ENERGY PARTNERS X, L.P. |
Delaware |
1427639 |
7 |
1427639 |
0 |
10954234 |
36.1 % |
18/10/2017 |
| Fund, L.P. |
Delaware |
0 |
468505 |
0 |
0 |
468505 |
1.8 % |
10/10/2017 |
| James E. Flynn |
Delaware |
0 |
937010 |
0 |
0 |
937010 |
3.59 % |
10/10/2017 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
468505 |
0 |
0 |
468505 |
1.8 % |
10/10/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
468505 |
0 |
0 |
468505 |
1.8 % |
10/10/2017 |
| Company, L.P. |
Delaware |
0 |
937010 |
0 |
0 |
937010 |
3.59 % |
10/10/2017 |
| Mgmt III, L.P. |
Delaware |
0 |
468505 |
0 |
0 |
468505 |
1.8 % |
10/10/2017 |