| INGALLS & SNYDER LLC |
NEW YORK |
3466268 |
3466268 |
3466268 |
0 |
3466268 |
4.8 % |
23/04/2026 |
| The Vanguard Group |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
0 |
0 % |
27/03/2026 |
| The Vanguard Group |
PENNSYLVANIA |
4013315 |
4013315 |
4013315 |
0 |
4013315 |
5.66 % |
30/01/2026 |
| The Vanguard Group |
PENNSYLVANIA |
459738 |
459738 |
459738 |
0 |
3346958 |
4.91 % |
31/10/2025 |
| INGALLS & SNYDER LLC |
NEW YORK |
4161315 |
4161315 |
4161315 |
0 |
4161315 |
7.2 % |
21/02/2025 |
| (1) BlackRock, Inc. |
Delaware |
4218026 |
0 |
4279836 |
0 |
4279836 |
6.8 % |
29/01/2024 |
| (1) BlackRock, Inc. |
Delaware |
1224228 |
0 |
1225787 |
0 |
1225787 |
2 % |
08/07/2022 |
| Cormorant Asset Management, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Bihua Chen |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
113983 |
3199505 |
158323 |
3357828 |
5.37 % |
10/02/2022 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
4464492 |
4464492 |
7.1 % |
04/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
3974260 |
0 |
4050028 |
0 |
4050028 |
6.5 % |
02/02/2022 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2021 |
| Mitchell Blutt |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2021 |
| Consonance Capital Management LP |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2021 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2021 |
| Cormorant Asset Management, LP |
Cayman Islands |
0 |
5000000 |
0 |
5000000 |
5000000 |
8.1 % |
16/02/2021 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
4803167 |
0 |
4803167 |
4803167 |
7.8 % |
16/02/2021 |
| Cormorant Global Healthcare GP, LLC |
Cayman Islands |
0 |
4803167 |
0 |
4803167 |
4803167 |
7.8 % |
16/02/2021 |
| Bihua Chen |
Cayman Islands |
0 |
5000000 |
0 |
5000000 |
5000000 |
8.1 % |
16/02/2021 |
| Consonance Capital Management LP |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
6058505 |
0 |
0 |
6058505 |
9.99 % |
16/02/2021 |
| Mitchell Blutt |
USA |
0 |
6058505 |
0 |
0 |
6058505 |
9.99 % |
16/02/2021 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
1193518 |
0 |
0 |
1193518 |
2.04 % |
16/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
0 |
3014584 |
177821 |
3192405 |
5.18 % |
10/02/2021 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
4748189 |
4748189 |
7.7 % |
09/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
5208679 |
0 |
5384022 |
0 |
5384022 |
8.7 % |
29/01/2021 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
2835427 |
0 |
2835427 |
2835427 |
5.2 % |
04/05/2020 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
2835427 |
0 |
2835427 |
2835427 |
5.2 % |
04/05/2020 |
| Cormorant Asset Management, LP |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
5.5 % |
04/05/2020 |
| Bihua Chen |
United States |
0 |
3000000 |
0 |
3000000 |
3000000 |
5.5 % |
04/05/2020 |
| Gregory A. Demopulos, M.D. |
United States |
4999884 |
0 |
4999884 |
4999884 |
4999884 |
8.75 % |
14/02/2020 |
| Mitchell Blutt |
USA |
0 |
3195796 |
0 |
0 |
3195796 |
6.42 % |
14/02/2020 |
| Consonance Capital Management LP |
Delaware USA |
0 |
2982797 |
0 |
0 |
2982797 |
6 % |
14/02/2020 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
212999 |
0 |
0 |
212999 |
0.43 % |
14/02/2020 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
3195796 |
0 |
0 |
3195796 |
6.42 % |
14/02/2020 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
5030671 |
5030671 |
9.39 % |
07/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
3952792 |
0 |
4062623 |
0 |
4062623 |
7.6 % |
05/02/2020 |
| 13-3695715 |
Delaware |
0 |
2439072 |
0 |
0 |
2461172 |
5 % |
10/05/2019 |
| David E. Shaw |
United States |
0 |
2439072 |
0 |
0 |
2461172 |
5 % |
10/05/2019 |
| 8.96% † |
United States |
4621363 |
0 |
4621363 |
0 |
4621363 |
8.96 % |
13/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
3884507 |
0 |
3989206 |
0 |
3989206 |
8.1 % |
06/02/2019 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
5582273 |
5582273 |
11.4 % |
30/01/2019 |
| 8.4%2 |
United States |
42397151 |
0 |
42397151 |
0 |
42397151 |
8.4 % |
14/02/2018 |
| Bihua Chen |
United States |
0 |
900000 |
0 |
0 |
900000 |
1.87 % |
14/02/2018 |
| Cormorant Asset Management, LLC |
Delaware |
0 |
900000 |
0 |
0 |
900000 |
1.87 % |
14/02/2018 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
749845 |
0 |
0 |
749845 |
1.56 % |
14/02/2018 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
749845 |
0 |
0 |
749845 |
1.56 % |
14/02/2018 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
5714180 |
5714180 |
11.9 % |
09/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
3845772 |
0 |
3930578 |
0 |
3930578 |
8.2 % |
29/01/2018 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
2449646 |
0 |
0 |
2449646 |
4.2 % |
07/11/2017 |
| Bihua Chen |
United States |
0 |
2450000 |
0 |
0 |
2450000 |
5.1 % |
07/11/2017 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
2449646 |
0 |
0 |
2449646 |
4.2 % |
07/11/2017 |
| Cormorant Asset Management, LLC |
Delaware |
0 |
2450000 |
0 |
0 |
2450000 |
5.1 % |
07/11/2017 |
| Gregory A. Demopulos, M.D. |
United States |
3825659 |
0 |
3825659 |
0 |
3825659 |
8.4 % |
14/02/2017 |
| Cormorant Global Healthcare GP, LLC |
Cayman Islands |
0 |
821438 |
0 |
0 |
821438 |
1.9 % |
14/02/2017 |
| Cormorant Asset Management, LLC |
Cayman Islands |
0 |
975000 |
0 |
0 |
975000 |
2.7 % |
14/02/2017 |
| Bihua Chen |
Cayman Islands |
0 |
975000 |
0 |
0 |
975000 |
2.7 % |
14/02/2017 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
821438 |
0 |
0 |
821438 |
1.9 % |
14/02/2017 |
| Cormorant Asset Management, LLC |
Delaware |
0 |
975000 |
0 |
0 |
975000 |
2.7 % |
14/02/2017 |
| Bihua Chen |
United States |
0 |
975000 |
0 |
0 |
975000 |
2.7 % |
14/02/2017 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
821438 |
0 |
0 |
821438 |
1.9 % |
14/02/2017 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
821438 |
0 |
0 |
821438 |
1.9 % |
14/02/2017 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
5097510 |
5097510 |
11.87 % |
14/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
3164866 |
0 |
3234999 |
0 |
3234999 |
7.5 % |
25/01/2017 |
| 10.0%2 |
United States |
40655141 |
0 |
40655141 |
0 |
40655141 |
10 % |
01/03/2016 |
| 9.7%2 |
United States |
39196801 |
0 |
39196801 |
0 |
39196801 |
9.7 % |
11/02/2016 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
3760620 |
3760620 |
9.9 % |
05/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
2485970 |
0 |
2554983 |
0 |
2554983 |
6.7 % |
27/01/2016 |
| 98-0557567 |
Bermuda |
333 |
0 |
333 |
0 |
333 |
0 % |
13/10/2015 |
| Cormorant Asset Management, LLC |
Cayman Islands |
0 |
1960000 |
0 |
0 |
1960000 |
5.2 % |
28/09/2015 |
| Cormorant Global Healthcare GP, LLC |
Cayman Islands |
0 |
1960000 |
0 |
0 |
1960000 |
5.2 % |
28/09/2015 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1960000 |
0 |
0 |
1960000 |
5.2 % |
28/09/2015 |
| Bihua Chen |
Cayman Islands |
0 |
1960000 |
0 |
0 |
1960000 |
5.2 % |
28/09/2015 |
| 98-0557567 |
Bermuda |
3852547 |
0 |
3852547 |
0 |
3852547 |
10.2 % |
10/08/2015 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
2347987 |
2347987 |
6.9 % |
06/02/2015 |
| (1) BlackRock, Inc. |
Delaware |
1890513 |
0 |
1953307 |
0 |
1953307 |
5.7 % |
02/02/2015 |
| 10.1%2 |
United States |
36621821 |
0 |
36621821 |
0 |
36621821 |
10.1 % |
16/01/2015 |
| (1) BlackRock, Inc. |
Delaware |
1618175 |
0 |
1669665 |
0 |
1669665 |
4.9 % |
07/08/2014 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
1717860 |
1717860 |
5.1 % |
01/04/2014 |
| Peter Kolchinsky |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2014 |
| RA Capital Healthcare Fund, L.P. |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2014 |
| RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2014 |
| 10.4%2 |
United States |
33315591 |
0 |
33315591 |
0 |
33315591 |
10.4 % |
12/02/2014 |
| (1) BlackRock, Inc. |
Delaware |
1554061 |
0 |
1603760 |
0 |
1603760 |
5.3 % |
29/01/2014 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
1293985 |
1293985 |
4.3 % |
11/07/2013 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1993278 |
0 |
0 |
1993278 |
6.7 % |
20/05/2013 |
| Peter Kolchinsky |
Citizenship or Place of Organization |
0 |
2953004 |
0 |
0 |
2953004 |
9.9 % |
20/05/2013 |
| RA Capital Management, LLC |
Massachusetts |
0 |
2953004 |
0 |
0 |
2953004 |
9.9 % |
20/05/2013 |
| 13-5156620 |
NEW YORK STATE |
0 |
0 |
0 |
1322885 |
1322885 |
5.1 % |
11/04/2013 |
| Gregory A. Demopulos, M.D. |
United States |
3058123 |
0 |
3058123 |
3058123 |
3058123 |
11.1 % |
22/01/2013 |
| Gregory A. Demopulos, M.D. |
United States |
2784789 |
0 |
2784789 |
2784789 |
2784789 |
11.8 % |
13/01/2012 |
| Gregory A. Demopulos, M.D. |
United States |
2686760 |
0 |
2686760 |
2686760 |
2686760 |
11.8 % |
24/01/2011 |