| Vestal Point Capital, LP |
DELAWARE |
5425000 |
5425000 |
5425000 |
0 |
5425000 |
8.3 % |
15/05/2026 |
| JANUS HENDERSON GROUP PLC |
JERSEY |
3339218 |
3339218 |
3339218 |
0 |
3339218 |
5.1 % |
15/05/2026 |
| Deep Track Capital, LP |
DELAWARE |
4062500 |
4062500 |
4062500 |
0 |
4062500 |
6.21 % |
15/05/2026 |
| Red Tree GP, LLC |
DELAWARE |
3170509 |
3170509 |
3170509 |
0 |
3170509 |
4.8 % |
08/05/2026 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
2100929 |
3.2 % |
06/05/2026 |
| T. Rowe Price Investment Management, Inc. |
MARYLAND |
0 |
0 |
0 |
0 |
6605780 |
10.1 % |
08/04/2026 |
| Rajeev Shah |
UNITED STATES |
0 |
7279739 |
0 |
7279739 |
7279739 |
11.5 % |
02/03/2026 |
| RA Capital Healthcare Fund, L.P. |
DE |
0 |
4603418 |
0 |
4603418 |
4603418 |
7.3 % |
02/03/2026 |
| Peter Kolchinsky |
UNITED STATES |
0 |
7279739 |
0 |
7279739 |
7279739 |
11.5 % |
02/03/2026 |
| RA Capital Management, L.P. |
DE |
0 |
7279739 |
0 |
7279739 |
7279739 |
11.5 % |
02/03/2026 |
| Vestal Point Capital, LP |
DELAWARE |
3575000 |
3575000 |
3575000 |
0 |
3575000 |
6.5 % |
17/02/2026 |
| T. Rowe Price Investment Management, Inc. |
MARYLAND |
0 |
0 |
0 |
0 |
3236595 |
5.9 % |
17/02/2026 |
| Deep Track Capital, LP |
DELAWARE |
2750000 |
2750000 |
2750000 |
0 |
2750000 |
5.02 % |
12/02/2026 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
3347223 |
6.1 % |
05/02/2026 |
| Vestal Point Capital, LP |
DELAWARE |
5000000 |
5000000 |
5000000 |
0 |
5000000 |
9.2 % |
14/08/2025 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
2756217 |
5.1 % |
17/07/2025 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
2538404 |
4.7 % |
17/07/2025 |
| Vestal Point Capital, LP |
DELAWARE |
2768975 |
2768975 |
2768975 |
0 |
2768975 |
5.1 % |
15/05/2025 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
3611573 |
6.6 % |
12/05/2025 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
2803807 |
5.2 % |
03/03/2025 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
2117088 |
3.9 % |
12/02/2025 |
| 13G |
Bermuda |
3041286 |
0 |
3041286 |
0 |
3041286 |
5.6 % |
26/09/2024 |
| 13G |
Bermuda |
3041286 |
0 |
3041286 |
0 |
3041286 |
5.6 % |
26/09/2024 |
| 13G |
Bermuda |
3041286 |
0 |
3041286 |
0 |
3041286 |
5.6 % |
26/09/2024 |
| 13G |
Bermuda |
31541 |
0 |
31541 |
0 |
31541 |
0.1 % |
26/09/2024 |
| 13G |
Bermuda |
31541 |
0 |
31541 |
0 |
31541 |
0.1 % |
26/09/2024 |
| 13G |
Bermuda |
3072827 |
0 |
3072827 |
0 |
3072827 |
5.7 % |
26/09/2024 |
| 13G |
Bermuda |
31541 |
0 |
31541 |
0 |
31541 |
0.1 % |
26/09/2024 |
| 13G |
Bermuda |
3041286 |
0 |
3041286 |
0 |
3041286 |
5.6 % |
26/09/2024 |
| Red Tree Venture Fund, L.P. |
Delaware |
0 |
3170509 |
0 |
0 |
3170509 |
5.8 % |
26/09/2024 |
| Heath Lukatch |
Delaware |
0 |
3170509 |
0 |
0 |
3170509 |
5.8 % |
26/09/2024 |
| Red Tree GP, LLC |
Delaware |
0 |
3170509 |
0 |
0 |
3170509 |
5.8 % |
26/09/2024 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4303418 |
0 |
10 |
4303418 |
7.9 % |
23/09/2024 |
| RA Capital Management, L.P. |
Delaware |
0 |
6955993 |
0 |
10 |
6955993 |
12.8 % |
23/09/2024 |
| Rajeev Shah |
United States |
0 |
6955993 |
0 |
10 |
6955993 |
12.8 % |
23/09/2024 |
| Peter Kolchinsky |
United States |
0 |
6955993 |
0 |
10 |
6955993 |
12.8 % |
23/09/2024 |
| Jon Winkelried |
United States of America |
0 |
3010425 |
0 |
0 |
3010425 |
5.5 % |
18/09/2024 |
| James G. Coulter |
United States of America |
0 |
3010425 |
0 |
0 |
3010425 |
5.5 % |
18/09/2024 |
| TPG GP A, LLC |
Delaware |
0 |
3010425 |
0 |
0 |
3010425 |
5.5 % |
18/09/2024 |
| David Bonderman |
United States of America |
0 |
3010425 |
0 |
0 |
3010425 |
5.5 % |
18/09/2024 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
2495333 |
0 |
2495333 |
5.095 % |
18/09/2024 |
| FMR LLC |
Delaware |
2495333 |
0 |
2495333 |
0 |
2495333 |
5.095 % |
18/09/2024 |
